Clinical and genetic aspects of spastic paraplegia
نویسندگان
چکیده
منابع مشابه
Clinical and genetic study of hereditary spastic paraplegia in Canada
OBJECTIVE To describe the clinical, genetic, and epidemiologic features of hereditary spastic paraplegia (HSP) in Canada and to determine which clinical, radiologic, and genetic factors determine functional outcomes for patients with HSP. METHODS We conducted a multicenter observational study of patients who met clinical criteria for the diagnosis of HSP in the provinces of Alberta, Ontario, ...
متن کاملHereditary spastic paraplegia: Clinical-genetic characteristics and evolving molecular mechanisms
Hereditary spastic paraplegia (HSP) is a group of clinically and genetically heterogeneous neurological disorders characterized by pathophysiologic hallmark of length-dependent distal axonal degeneration of the corticospinal tracts. The prominent features of this pathological condition are progressive spasticity and weakness of the lower limbs. To date, 72 spastic gait disease-loci and 55 spast...
متن کاملGenetic and phenotypic characterization of complex hereditary spastic paraplegia
The hereditary spastic paraplegias are a heterogeneous group of degenerative disorders that are clinically classified as either pure with predominant lower limb spasticity, or complex where spastic paraplegia is complicated with additional neurological features, and are inherited in autosomal dominant, autosomal recessive or X-linked patterns. Genetic defects have been identified in over 40 dif...
متن کاملClinical features and management of hereditary spastic paraplegia.
Hereditary spastic paraplegia (HSP) is a group of genetically-determined disorders characterized by progressive spasticity and weakness of lower limbs. An apparently sporadic case of adult-onset spastic paraplegia is a frequent clinical problem and a significant proportion of cases are likely to be of genetic origin. HSP is clinically divided into pure and complicated forms. The later present w...
متن کاملHereditary "pure" spastic paraplegia: a clinical and genetic study of 22 families.
In 22 families with the "pure" form of hereditary spastic paraplegia inheritance was autosomal dominant in 19 and autosomal recessive in three. Examination of intrafamilial correlation of age of onset in the dominant cases suggested that the disorder is genetically heterogeneous. Two forms of dominant hereditary spastic paraplegia were identified: one with an age of onset mostly below 35 years ...
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ژورنال
عنوان ژورنال: Frontiers in Neuroscience
سال: 2010
ISSN: 1662-453X
DOI: 10.3389/conf.fnins.2010.12.00024